Scientific Publications

  • Kannappan V, Liu Y, Wang Z, Azar K, Kurusamy S, Kilari RS, Armesilla AL, Morris MR, Najlah M, Liu P, Bian XW, Wang W. PLGA-Nano-Encapsulated Disulfiram Inhibits Hypoxia-Induced NF-κB, Cancer Stem Cells, and Targets Glioblastoma In Vitro and In Vivo. Mol Cancer Ther. 2022 Aug 2;21(8):1273-1284. doi:10.1158/1535-7163.MCT-22-0066.
  • Kannappan V, Ali M, Small B, Rajendran G, Elzhenni S, Taj H, Wang W, Dou QP. Recent Advances in Repurposing Disulfiram and Disulfiram Derivatives as Copper-Dependent Anticancer Agents. Front Mol Biosci. 2021 Sep 17;8:741316. doi: 10.3389/fmolb.2021.741316.
  • Najlah M, Said Suliman A, Tolaymat I, Kurusamy S, Kannappan V, Elhissi AMA, Wang W. Development of Injectable PEGylated Liposome Encapsulating Disulfiram for Colorectal Cancer Treatment. Pharmaceutics. 2019 Nov 14;11(11):610. doi: 10.3390/pharmaceutics11110610.
  • Butcher K, Kannappan V, Kilari RS, Morris MR, McConville C, Armesilla AL, Wang W. Investigation of the key chemical structures involved in the anticancer activity of disulfiram in A549 non-small cell lung cancer cell line. BMC Cancer. 2018 Jul 21;18(1):753. doi: 10.1186/s12885-018-4617-x.
  • Xu B, Wang S, Li R, Chen K, He L, Deng M, Kannappan V, Zha J, Dong H, Wang W. Disulfiram/copper selectively eradicates AML leukemia stem cells in vitro and in vivo by simultaneous induction of ROS-JNK and inhibition of NF-κB and Nrf2. Cell Death Dis. 2017 May 18;8(5):e2797. doi: 10.1038/cddis.2017.176.
  • Kannappan V, Butcher K, Trela M, Nicholl I, Wang W, Attridge K. Interleukin 21 inhibits cancer-mediated FOXP3 induction in naïve human CD4 T cells. Cancer Immunol Immunother. 2017 May;66(5):637-645. doi: 10.1007/s00262-017-1970-6. Epub 2017 Feb 27.
  • Zhao H, Shi P, Deng M, Jiang Z, Li Y, Kannappan V, Wang W, Li P, Xu B. Low dose triptolide reverses chemoresistance in adult acute lymphoblastic leukemia cells via reactive oxygen species generation and DNA damage response disruption. Oncotarget. 2016 Dec 20;7(51):85515-85528. doi: 10.18632/oncotarget.13454.
  • Tawari PE, Wang Z, Najlah M, Tsang CW, Kannappan V, Liu P, McConville C, He B, Armesilla AL, Wang W. The cytotoxic mechanisms of disulfiram and copper(ii) in cancer cells. Toxicol Res (Camb). 2015 Nov 19;4(6):1439-1442. doi: 10.1039/c5tx00210a. Epub 2015 Sep 10.
  • Wang Z, Tan J, McConville C, Kannappan V, Tawari PE, Brown J, Ding J, Armesilla AL, Irache JM, Mei QB, Tan Y, Liu Y, Jiang W, Bian XW, Wang W. Polylactic-co-glycolic acid controlled delivery of disulfiram to target liver cancer stem-like cells. Nanomedicine. 2017 Feb;13(2):641-657. doi: 10.1016/j.nano.2016.08.001. Epub 2016 Aug 10.
  • Zhou D, Kannappan V, Chen X, Li J, Leng X, Zhang J, Xuan S. RBP2 induces stem-like cancer cells by promoting EMT and is a prognostic marker for renal cell carcinoma. Exp Mol Med. 2016 Jun 10;48(6):e238. doi: 10.1038/emm.2016.37.
  • Liu P, Wang Z, Brown S, Kannappan V, Tawari PE, Jiang W, Irache JM, Tang JZ, Armesilla AL, Darling JL, Tang X, Wang W. Liposome encapsulated Disulfiram inhibits NFκB pathway and targets breast cancer stem cells in vitro and in vivo. Oncotarget. 2014 Sep 15;5(17):7471-85. doi: 10.18632/oncotarget.2166.
  • Liu P, Kumar IS, Brown S, Kannappan V, Tawari PE, Tang JZ, Jiang W, Armesilla AL, Darling JL, Wang W. Disulfiram targets cancer stem-like cells and reverses resistance and cross-resistance in acquired paclitaxel-resistant triple-negative breast cancer cells. Br J Cancer. 2013 Oct 1;109(7):1876-85. doi: 10.1038/bjc.2013.534. Epub 2013 Sep 5.
  • Liu P, Brown S, Channathodiyil P, Kannappan V, Armesilla AL, Darling JL, Wang W. Reply: Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells. Br J Cancer. 2013 Mar 5;108(4):994. doi: 10.1038/bjc.2013.19. Epub 2013 Jan 22.
  • Liu P, Brown S, Goktug T, Channathodiyil P, Kannappan V, Hugnot JP, Guichet PO, Bian X, Armesilla AL, Darling JL, Wang W. Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells. Br J Cancer. 2012 Oct 23;107(9):1488-97. doi: 10.1038/bjc.2012.442. Epub 2012 Oct 2.
  • Yip NC, Fombon IS, Liu P, Brown S, Kannappan V, Armesilla AL, Xu B, Cassidy J, Darling JL, Wang W. Disulfiram modulated ROS-MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties. Br J Cancer. 2011 May 10;104(10):1564-74. doi: 10.1038/bjc.2011.126. Epub 2011 Apr 12.
  • Gupta A, Briffa SM, Swingler S, Gibson H, Kannappan V, Adamus G, Kowalczuk M, Martin C, Radecka I. Synthesis of Silver Nanoparticles Using Curcumin-Cyclodextrins Loaded into Bacterial Cellulose-Based Hydrogels for Wound Dressing Applications. Biomacromolecules. 2020 May 11;21(5):1802-1811. doi: 10.1021/acs.biomac.9b01724. Epub 2020 Jan 30.